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KMID : 0378019890320070093
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New Medical Journal
1989 Volume.32 No. 7 p.93 ~ p.99
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Clinical Studies on the Effect Cosmsin^(®)(Cefuzonam Sodium, L-105) for Surgical Infection
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양정현/Yang, Jung Hyun
이종근/이희정/이찬영/Lee, Jong Keun/Lee, Hee Jung/Lee, Chan Young
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Abstract
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Cosmosin®(Cefuzonam Sodium, L-105), a new broad-spectrum antimicrobial agent, was administered to 30 patients, with proven microbial infection in surgical field, including intraabdominal infection, wound infection, biliary infection and soft tissue infection fro, Feb. 1 989 to May 1989. Most patients received daily 2 g doses of Cosmosin® for at lea- 4 days.
Prior antibiotics in patients receiving Cosmosin® were used in 22 patients, and Cosmosin®. was used initially in 8 patients.
The overall clinical response rate was 90% (27 of 30 patients).
The bacteriologic response rate was 76.6% (23 of 30 patients). Adverse reaction occurred in one case, but none were serious.
Elevation of serum aminotransferase was observed in 5 cases of patients, and elevation of
serum creatinine was observed in one case of patient. Cosmosin® is effective for the treatment of intra-abdominal infection, wound infection, biliary. infection. and soft tissue infection
in surgical field.
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